The 4180 had a number of changes to meet emissions and federal 'anti-tamper' regulations.
Metering plates instead of jets, capped idle adjuster screws, float bowls vented to a charcoal canister, etc....
It also had annular boosters which is a nice feature that helps with atomization.
I'm running a 650 AVS at the moment and have both 650 and 750 Holley 4160's on the shelf.
They all run well with my fairly stock engine and a Performer intake.
With the tighter runners of a stock intake and the retarded cam timing from the factory you are probably better off with a 600 or 650 carb.
Change the stock 8* retarded timing set for 'straight up' and you will notice the difference.
Jim,
Lil'Red is a '87 F250 HD, 4.10's, 1356 4x4, Zf-5, 3G, PMGR, Saginaw PS, desmogged with a Holley 80508 and Performer intake.
Too much other stuff to mention.