1) You need to adjust your ignition timing/curve and fuel mixture to where you don't experience preignition.
This is all a part of setting up the distributor and jetting the 4V carb.
2) Yeah, you need vacuum advance and PCV.
Without knowing exactly which carb and spacer you have I can't say what ports they have.
Edit: generally vacuum advance would go to ported vacuum on the side of a carb and PCV goes to the large port in the base flange.
You certainly need vacuum for your brake booster and to run the climate control.
I'm not sure if you have speed control, but that has a vacuum servo too.
Climate and cruise meet at a junction mounted to the center of the cowl high on the firewall.
Brakes usually go directly to a larger vacuum nipple on the intake manifold.
Jim,
Lil'Red is a '87 F250 HD, 4.10's, 1356 4x4, Zf-5, 3G, PMGR, Saginaw PS, desmogged with a Holley 80508 and Performer intake.
Too much other stuff to mention.