Unfortunately, brake fluid will eat the booster diaphragm.
Usually you will hear hissing under the dash.
Did you look carefully between the midship tank and the frame rail, and also where the hard line pokes through the crossmember to join the hose to the rear axle?
Rust through is most common in these areas.
Ideally these problems are easy to fix with the new copper/nickel line.
Jim,
Lil'Red is a '87 F250 HD, 4.10's, 1356 4x4, Zf-5, 3G, PMGR, Saginaw PS, desmogged with a Holley 80508 and Performer intake.
Too much other stuff to mention.