Be careful as the power to the fuse box and ignition switch goes through fuselinks - short pieces of smaller wire with a special insulation on it that won't melt. They serve as the circuit protection to things in the cab and some form of protection is necessary.
If it was mine I'd probably do what I did on Big Blue or others have done - install a relay/fuse box combo on the fender near the starter relay. Use the fuse slots to replace the fuselinks and the run new wire to the ignition and factory fuse box.
But, since you'd have relay spots I'd then install relays to power the headlights. Use the existing headlight wire to trigger the relays and you'll have much brighter lights. And, if you really want to make your HVAC blower work better put in relays to provide the ground and power to it.
Several of us have done all of that and can help you through it. Oh yes, unless you put in a really heavy wire, like #10 or at least #12 gauge, to the HEI you won't get full power out of it. So I'd run a relay that provides serious power to the ignition.
Gary, AKA "Gary fellow":
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Dad's: '81 F150 Ranger XLT 4x4: Down for restomod: Full-roller "stroked 351M" w/Trick Flow heads & intake, EEC-V SEFI/E4OD/3.50 gears w/Kevlar clutches
Blue: 2015 F150 Platinum 4x4 SuperCrew wearing Blue Jeans & sporting a 3.5L EB & Max Tow
Big Blue: 1985 F250HD 4x4: 460/ZF5/3.55's, D60 w/Ox locker & 10.25 Sterling/Trutrac, Blue Top & Borgeson, & EEC-V MAF/SEFI