The C5 should bolt right on.
But I can't say whether the driveshaft will fit, although you should be able to figure that out by looking at the page at Documentation/Driveline/Driveshafts. The main question will be the length, which that gives you.
However, the radiator won't work. All gas-powered V8's use a radiator with the inlet on the passenger's side and the outlet on the driver's side. But the 300 six uses one with the connections just reversed.
And you will for sure need the right perches & exhaust, and probably a few other things like the throttle cable. You can see a bit of that on our page at Documentation/
Engines/Engine Swaps (don't go to the 300 Six To 302 page). There's a list of things as well as a link to another page on Engine Perches/Stands/Brackets.
Gary, AKA "Gary fellow":
Profile
Dad's: '81 F150 Ranger XLT 4x4: Down for restomod: Full-roller "stroked 351M" w/Trick Flow heads & intake, EEC-V SEFI/E4OD/3.50 gears w/Kevlar clutches
Blue: 2015 F150 Platinum 4x4 SuperCrew wearing Blue Jeans & sporting a 3.5L EB & Max Tow
Big Blue: 1985 F250HD 4x4: 460/ZF5/3.55's, D60 w/Ox locker & 10.25 Sterling/Trutrac, Blue Top & Borgeson, & EEC-V MAF/SEFI