Hi George!
No, it will not bolt up.
300/4.9 shares a bell pattern with the Windsor engines.
The 460 and Diesel patterns are close (one bolt off) but still not close enough to each other.
Down to the flywheel & starter mostly.,
Jim,
Lil'Red is a '87 F250 HD, 4.10's, 1356 4x4, Zf-5, 3G, PMGR, Saginaw PS, desmogged with a Holley 80508 and Performer intake.
Too much other stuff to mention.