I recently pulled the manifolds and head on my 300 in an '85 carbureted F150.
The idle was very rough and I had no information on this engine as a replacement by a previous owner, so decided to take them to a local, good machine shop. I noticed one of the gaskets - intake, I believe - had slipped on installation causing a leak and two valves were white.
An old trick is to spray carb cleaner or starter fluid around the manifold while the engine's running and before it gets too hot. If you hear a change in rpm, you've got a leak somewhere.
'85 F150 XLT 4X4 with 300 c.i. six & NP435 four speed.
'63 Studebaker Avanti - 350/TH350
'59 Rambler Super - OHV 6 with 3-speed OD
'58 Studebaker Scotsman sedan - 289 with 3-speed OD